The aim of this study was to investigate whether thymoquinone (TQ) could alleviate
diclofenac (DCLF)-induced gastrointestinal and renal toxicity in rats. Diclofenac was …

Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …

We have previously reported that perfluorooctanesulfonate (PFOS) causes cell apoptosis in
renal tubular epithelial cells (RTCs). Here, we extend our findings and provide evidence of …

The accumulation of advanced glycation end-products (AGEs) and the enhanced interaction
of AGE with their cellular receptor (RAGE) have been implicated in the progression of …

Introduction: The renin–angiotensin system and epithelial–mesenchymal transition play
crucial roles in the development of kidney fibrosis. The connection between the renin …

Acute kidney injury (AKI) is a major complication of sepsis. Nucleotide‐binding domain‐like
receptor protein 3 (NLRP3) inflammasomes are multiprotein complexes that mediate septic …

Acute kidney injury (AKI) is a clinical disorder with a serious impact on the quality of patients'
lives. Considering its increased worldwide prevalence, investigating novel therapeutic …

Background. This study evaluated the impact of different doses of Astragalus
polysaccharides (APS) on the functional status and phenotype of T cells during …

Background: Sepsis is a severe inflammatory response to infection. Excessive
compensation to inflammation leads to dysregulated immune response that ultimately …

AIM: To investigate whether resveratrol (3, 4, 5-trihydroxy-trans-stilbene) inhibits collagen I
synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore …