This paper reviews the recent advances in knowledge of brainstem mechanisms related to
craniofacial pain. It also draws attention to their clinical implications, and concludes with a …

Chronic primary orofacial pain (OFP) conditions such as painful temporomandibular
disorders (pTMDs; ie, myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN) …

We have previously shown that injection of the inflammatory irritant and small-fiber excitant
mustard oil (MO) into the temporomandibular joint (TMJ) region can reflexively induce a …

Injection of glutamate into the rat temporomandibular joint (TMJ) capsule can reflexly induce
a prolonged increase in the electromyographic (EMG) activity of the jaw muscles, however …

The aim of this study was to further validate our carrageenan-induced temporomandibular
joint (TMJ) inflammatory hyperalgesia model in rats by showing that administration of …

Temporomandibular disorders represent one of the major challenges in dentistry
therapeutics. This study was undertaken to evaluate the time course of carrageenan …

Behavioral, electrophysiological, and autoradiographic experiments were done to study the
second nociceptive phase in the formalin test. In initial experiments, this second phase was …

Aim: To test whether orofacial mechanical and thermal hypersensitivities occur in rats during
orthodontic tooth movement (OTM). Methods: Sprague-Dawley rats (140 to 160 g) were …

Aims: To test the hypotheses that masseteric inflammation produces a reduction of mean
bite force and success rates and that classical anti-inflammatory agents prevent …

We have previously documented that peripheral N-methyl-d-aspartate (NMDA) receptor
mechanisms are involved in nociceptive reflex increases in jaw muscle activity to injection of …