IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …

Since immunoglobulin A nephropathy (IgAN) was first described in the seminal papers by
Berger [1, 2], we have learned much descriptively about its epidemiology, associations …

End-stage renal disease (ESRD) is a major public health problem, affecting 1 in 1,000
individuals and with an annual death rate of 20% despite dialysis treatment 1, 2. IgA …

African Americans have higher overall incidence rates of end-stage renal disease (ESRD)
compared with American whites. Hypertensive nephrosclerosis (HN), nephropathy …

Nephrosclerosis is literally defined as hardening of the kidneys (Greek derivation: nephros,
kidney; sklerosis, hardening). It is the result of scarring or replacement of the normal renal …

IgA vasculitis with nephritis (IgAVN) shares many pathogenetic features with IgA
nephropathy (IgAN). The purpose of this review is to describe our current understanding of …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world among
patients undergoing renal biopsy. Approximately 30% of patients with IgAN develop end …

In IgA nephropathy (IgAN), there is dysregulation of the IgA response to a wide range of
antigens. The dysregulation promotes synthesis of polymeric IgA1 (pIgA1) with …

Evidence for genetic factors in the development and progression of IgA nephropathy.
Background IgA nephropathy (IgAN) is the most common glomerulonephritis in the world …

Recent genome-wide association studies (GWAS) have identified multiple susceptibility loci
for immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis …