Studies of molecular and cellular interactions involved in the pathogenesis of IgA
nephropathy have revealed the autoimmune nature of this most common primary …

Under resting conditions, about 20% of the cardiac output in humans perfuses the kidneys,
organs that constitute only about 0.5% of the human body mass. This rate of blood flow …

Henoch–Schönlein purpura (HSP) is the one of most common types of systemic vasculitis in
childhood. Glomerulonephritis (HSPN) occurs in 30–50% of HSP patients, mostly in a mild …

Primary IgA nephropathy (IgAN) is characterized by recurrent episodes of macroscopic
hematuria accompanied by upper respiratory tract infections or persistent asymptomatic …

Immunoglobulin A nephropathy (IgAN) is the most common form of primary
glomerulonephritis worldwide and an important cause of kidney disease in young adults …

IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and an important
cause of ESRD. Familial clustering of cases suggests genetic predisposition to this disease …

Several lines of evidence suggest that genetic factors have an important role in the
pathogenesis of immunoglobulin A (IgA) nephropathy. We report the prevalence of familial …

The Fc-α receptor (FcαR/CD89) is involved in IgA complex formation and may affect the
development of IgA nephropathy (IgAN). In this study, we tested the genetic variations of the …

IgA nephropathy is the most-common primary glomerulonephritis worldwide, and about 20%–
50% of patients develop progressive renal failure. The pathogenesis is still unknown and …

To explore the possibility that hereditary factors increase the risk for end-stage renal disease
(ESRD), 669 patients with ESRD in the province of Newfoundland, Canada from 1987 to …