Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in
response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory …

Diabetic kidney disease (DKD) is a prevalent and severe complications of diabetes and
serves as the primary cause of end-stage kidney disease (ESKD) globally. Increasing …

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus (DM).
However, the precise molecular mechanisms remain largely unclear, and it is still a …

Dysregulated inflammasome activity, particularly of the NLRP3 inflammasome, is associated
with the development of several inflammatory diseases. The study of molecules directly …

Drug-induced organ injury is one of the key factors causing organ failure and death in the
global public. Triptolide (TP) is the main immunosuppressive component of Tripterygium …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling
complex integral to the chronic inflammatory response, activated in response to sterile and …

Mounting evidence progressively appreciates the vital interplay between immunity and
metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and …