[HTML][HTML] Drug repurposing against KRAS mutant G12C: a machine learning, molecular docking, and molecular dynamics study

T Srisongkram, N Weerapreeyakul - International Journal of Molecular …, 2022 - mdpi.com
The Kirsten rat sarcoma viral G12C (KRASG12C) protein is one of the most common
mutations in non-small-cell lung cancer (NSCLC). KRASG12C inhibitors are promising for …

[HTML][HTML] Squamous cell lung cancer

BR Sabbula, DP Gasalberti, F Anjum - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Objectives:< p> Identify the etiology of squamous cell lung cancer.</p>< p> Review the
appropriate history, physical, and evaluation of squamous cell lung cancer.</p>< p> Outline …

[HTML][HTML] Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma

OK Graves, W Kim, M Özcan, S Ashraf, H Turkez… - Biomedicine & …, 2023 - Elsevier
Background Lung adenocarcinoma (LUAD) is the one of the most common subtypes in lung
cancer. Although various targeted therapies have been used in the clinical practice, the 5 …

[HTML][HTML] Current challenges and practical aspects of molecular pathology for non-small cell lung cancers

P Hofman, S Berezowska, D Kazdal, B Mograbi, M Ilié… - Virchows Archiv, 2024 - Springer
The continuing evolution of treatment options in thoracic oncology requires the pathologist to
regularly update diagnostic algorithms for management of tumor samples. It is essential to …

Arterial chemotherapy for hepatocellular carcinoma in China: consensus recommendations

M Zhao, Z Guo, YH Zou, X Li, ZP Yan, MS Chen… - Hepatology …, 2024 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third
leading cause of cancer-related deaths globally. Hepatic arterial infusion chemotherapy …

Canakinumab versus placebo in combination with first-line pembrolizumab plus chemotherapy for advanced non–small-cell lung cancer: results from the CANOPY-1 …

DSW Tan, E Felip, G de Castro, BJ Solomon… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE The addition of checkpoint inhibitors to first-line treatment has prolonged survival
of patients with non–small-cell lung cancer (NSCLC), but prognosis remains poor, with new …

[HTML][HTML] Liquid biopsy in early-stage lung cancer: Current and Future Clinical Applications

O Vandekerckhove, K Cuppens, K Pat, B Du Pont… - Cancers, 2023 - mdpi.com
Simple Summary Early-stage disease non-small cell lung cancer has better outcomes than
advanced disease, but 5-year survival rates can drop to approximately 50% in cases of …

[HTML][HTML] Immune checkpoint inhibitors in non-small cell lung cancer: From current perspectives to future treatments—A systematic review

A Olivares-Hernández, EG Del Portillo… - Annals of …, 2023 - ncbi.nlm.nih.gov
Background The introduction of immunotherapy in the treatment of non-small cell lung
cancer (NSCLC) has resulted in a radical change in patients' treatment responses and …

[HTML][HTML] Circulating tumor DNA-based genomic profiling assays in adult solid tumors for precision oncology: recent advancements and future challenges

HT Chan, YM Chin, SK Low - Cancers, 2022 - mdpi.com
Simple Summary The use of liquid biopsy for tumor genomic profiling to identify genomic
biomarkers for targeted therapies has revolutionized the clinical practice in oncology …

Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy

Q Fang, J Yu, W Li, J Luo, Q Deng… - Clinical and …, 2023 - Wiley Online Library
Though immunotherapy has to some extent improved the prognosis of patients with
advanced non‐small cell lung cancer (NSCLC), only a few patients benefit. Furthermore …