[HTML][HTML] Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus

J Luo, T Ning, X Li, T Jiang, S Tan, D Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Diabetes is a common metabolic disease characterized by an imbalance in blood glucose
levels. The pathogenesis of diabetes involves the essential role of cytokines, particularly the …

Genetic insights into the relationship between immune cell characteristics and ischemic stroke: A bidirectional Mendelian randomization study

X Deng, S Hou, Y Wang, H Yang… - European Journal of …, 2024 - Wiley Online Library
Background and purpose Ischemic stroke, a major contributor to global disability and
mortality, is underpinned by intricate pathophysiological mechanisms, notably …

The genetic relationships between immune cell traits, circulating inflammatory proteins and preeclampsia/eclampsia

Y Liu, Y Zhang, L Du, D Chen - Frontiers in Immunology, 2024 - frontiersin.org
Objectives Preeclampsia/eclampsia (PE), a critical complication during pregnancy, has been
suggested to correlate with immune cell phenotypes and levels of circulating inflammatory …

Structural characterization of a proanthocyanidin-rich fraction from Hancornia speciosa leaves and its effect on the release of pro-inflammatory cytokines and oxidative …

WOC Junior, MLR Guimarães, KM Freitas… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance In Brazil, the leaves of Hancornia speciosa
Gomes have a traditional use for treating hypertension and diabetes. Experimental …

Evaluating the link between immune characteristics and attention deficit hyperactivity disorder through a bi-directional Mendelian randomization study

H Jue, C Dan-fei, L Fang-fang, Y Ke-pin… - Frontiers in …, 2024 - frontiersin.org
Context Despite the recognition of attention deficit hyperactivity disorder (ADHD) as a
multifaceted neurodevelopmental disorder, its core causes are still ambiguous. The …

Inflammatory age and its impact on age-related health in older Chinese adults

RZ Wang, WS Zhang, CQ Jiang, F Zhu, YL Jin… - Archives of Gerontology …, 2024 - Elsevier
Introduction A standardized measure for inflammaging is lacking. We introduced the
inflammatory age (iAge) as a quantification method and explored its associations with age …

[HTML][HTML] White blood cells and type 2 diabetes: A Mendelian randomization study

Y Bi, Y Gao, Y Xie, M Zhou, Z Liu, S Tian, C Sun - Plos one, 2024 - journals.plos.org
Background Observational studies have demonstrated an association between white blood
cells (WBC) subtypes and type 2 diabetes (T2D) risk. However, it is unknown whether this …

Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study

P Wu, S Xie, Y Cai, H Liu, Y Lv, Y Yang, Y He… - Frontiers in …, 2024 - frontiersin.org
Background Observational studies have indicated that immune dysregulation in primary
sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However …

The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin‐derived deteriorated tumors

W Gong, J Zhou, Y Hou, juan Zhang… - Skin Research and …, 2024 - Wiley Online Library
Objective Observational studies have identified a dual effect of circulating inflammatory
proteins and immune cells on cancer progression. However, the specific mechanisms of …

Causal role of immune cells in hypertension: a bidirectional Mendelian randomization study

X Zhang, G Li, W Wu, B Li - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Background Although Hypertension (HTN) is considered to be a cardiovascular disease
caused by multiple factors, the cause of it is still unknown. In this study, we aim to find out …