Human opiorphin protects enkephalins from degradation by human neutral endopeptidase
and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of …

Introduction Priapism is defined as an erectile disorder, in which erection persists
uncontrollably without sexual purpose. The precise mechanisms involved in the …

Management of acute and chronic pain has always been a key area of clinical research.
Enkephalinase inhibitors (EIs) seem to be promising as therapeutic agents having …

Peptidomics techniques have identified hundreds of peptides that are derived from proteins
present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular …

Priapism is defined as a persistent, painful erection that continues beyond, or is unrelated to,
sexual stimulation. It may be categorized as either ischemic (low/absent flow) or …

Background. The use of easily accessible biomarkers for assessing young patients' health is
weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of …

Human opiorphin QRFSR-peptide protects enkephalins from degradation by human neutral
endopeptidase (hNEP) and aminopeptidase-N (hAP-N) and inhibits pain perception in a …

Protecting enkephalins, endogenous opioid peptides released in response to nociceptive
stimuli, is an innovative approach for acute and neuropathic pain alleviation. This is …

Objectives Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-
degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in …

The scarcity and limited risk/benefit ratio of painkillers available on the market, in addition to
the opioid crisis, warrant reflection on new innovation strategies. The pharmacopoeia of …