Time-course of pain and salivary opiorphin release in response to oral capsaicin differ in burning mouth syndrome patients, temporomandibular disorders patients and …
IZ Alajbeg, E Vrbanovic, I Alajbeg, I Orabovic… - Clinical Oral …, 2024 - Springer
Objectives Opiorphin is an analgesic peptide released by salivary glands and capsaicin an
agonist of TRPV1 receptors eliciting burning sensations. The primary objective of this study …
agonist of TRPV1 receptors eliciting burning sensations. The primary objective of this study …
Zinc inhibits apoptosis and maintains NEP downregulation, induced by ropivacaine, in HaCaT cells
E Kontargiris, A Vadalouka, V Ragos… - Biological trace element …, 2012 - Springer
Abstract Zinc (Zn), a cell-protective metal against various toxic compounds, is the key agent
for neutral endopeptidase (NEP) functional structure. NEP is a zinc metalloenzyme which …
for neutral endopeptidase (NEP) functional structure. NEP is a zinc metalloenzyme which …
[HTML][HTML] Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells
Background Molecular mechanisms of intrinsic or acquired radioresistance serve as critical
barrier for curative therapy of head and neck squamous cell carcinoma (HNSCC) and …
barrier for curative therapy of head and neck squamous cell carcinoma (HNSCC) and …
[HTML][HTML] Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein
RD Mathison, JS Davison, AD Befus… - Journal of …, 2010 - Springer
The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted
investigation into other biologically based therapeutics, and identification of immune …
investigation into other biologically based therapeutics, and identification of immune …
Higher aminopeptidase activity determined by electroosmotic push–pull perfusion contributes to selective vulnerability of the hippocampal CA1 region to oxygen …
It has been known for over a century that the hippocampus, the center for learning and
memory in the brain, is selectively vulnerable to ischemic damage, with the CA1 being more …
memory in the brain, is selectively vulnerable to ischemic damage, with the CA1 being more …
The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology
KP Davies - The journal of sexual medicine, 2009 - Elsevier
Introduction The opiorphins are a newly characterized class of peptides that act as potent
endogenous neutral endopeptidase (NEP) inhibitors. Recent reports have suggested that …
endogenous neutral endopeptidase (NEP) inhibitors. Recent reports have suggested that …
Neurophysiology of corneal neuropathic pain and emerging pharmacotherapeutics
K Asiedu - Journal of Neuroscience Research, 2024 - Wiley Online Library
The altered activity generated by corneal neuronal injury can result in morphological and
physiological changes in the architecture of synaptic connections in the nervous system …
physiological changes in the architecture of synaptic connections in the nervous system …
[HTML][HTML] PROL1 is essential for xenograft tumor development in mice injected with the human prostate cancer cell-line, LNCaP, and modulates cell migration and …
A Mukherjee, A Park, KP Davies - Journal of men's health, 2022 - ncbi.nlm.nih.gov
Results: The present studies demonstrate that LNCaP cell-lines with consisitutive knock-out
of PROL1 fail to develop tumors when injected into both castrated and intact male mice …
of PROL1 fail to develop tumors when injected into both castrated and intact male mice …
Disentangling accelerated cognitive decline from the normal aging process and unraveling its genetic components: A neuroimaging-based deep learning approach
DISCUSSION We developed a novel deep-learning-based approach, leveraging dual-loss
Siamese ResNet to learn the normal aging-related cognitive decline slope and identified the …
Siamese ResNet to learn the normal aging-related cognitive decline slope and identified the …
Salivary opiorphin levels in anorexia nervosa: A case–control study
E Paszynska, M Dmitrzak-Weglarz… - The World Journal of …, 2018 - Taylor & Francis
Objectives: Opiorphin is a physiological inhibitor of peptidases inactivating endogenous
opioids displaying strong analgesic properties without undesirable side effects …
opioids displaying strong analgesic properties without undesirable side effects …