Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …

The number one cause of human fetal death are defects in heart development. Because the
human embryonic heart is inaccessible and the impacts of mutations, drugs, and …

Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

In vitro modelling the complex (patho‐) physiological conditions of the heart is a major
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …

Cardiovascular diseases are the most common cause of death globally. Accurately
modeling cardiac homeostasis, dysfunction, and drug response lies at the heart of cardiac …

The human cardiac organoid (hCO) is three-dimensional tissue model that is similar to an in
vivo organ and has great potential on heart development biology, disease modeling, drug …

Branchiomeric muscles of the head and neck originate in a population of cranial mesoderm
termed cardiopharyngeal mesoderm that also contains progenitor cells contributing to …

The use of human cardiac organoids (hCOs) as 3D in vitro models for cardiovascular
research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to …