Colorectal cancer (CRC) is the most preventable malignancy globally, with a high mortality
rate. Cancer stem cells (CSCs) are found previously in multiple types of cancer; CRC is one …

Acute myeloid leukemia is an aggressive hematopoietic stem cell malignancy with poor
outcomes despite the available treatment options including standard chemotherapy …

Despite recent advances in the treatment of acute myeloid leukemia (AML), there has been
limited success in targeting surface antigens in AML, in part due to shared expression …

This study aimed to identify a recommended phase II dose and evaluate the safety,
tolerability, pharmacokinetics/pharmacodynamics, and preliminary clinical activity of JNJ …

Targeted drug delivery using antibody–drug conjugates has attracted great attention due to
its enhanced therapeutic efficacy compared to traditional chemotherapy. However, the …

Background Gemtuzumab ozogamicin (GO), one of the first targeted drugs used in oncology,
consists of an anti-cluster of differentiation 33 (CD33) monoclonal antibody bound to a …

Leukaemia stem cells (LSCs) are the critical seed for the growth of haematological
malignancies, driving the clonal expansion that enables disease initiation, relapse and often …

Introduction The past decade has seen a sea change in the AML landscape with vastly
improved cognizance of molecular pathogenesis, clonal evolution, and importance of …

Delivery of therapeutics specifically to the disease site is the final goal for the field of drug
discovery. Considerable efforts in understanding disease biology have contributed to …

Unter den Tumorerkrankungen repräsentieren die oft tödlich verlaufenden urologischen
Tumore eine Entität mit einem erheblichen Anteil. Extrazelluläre Vesikel eröffnen als …