Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus
SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe …

Executioner caspases, when activated, cleave hundreds or thousands of substrates in the
cell to orchestrate apoptosis. In most animals, the executioner caspases have short …

The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1
and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5,
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …