Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

Subcellular organelle‐specific reagents for simultaneous tumor targeting, imaging, and
treatment are of enormous interest in cancer therapy. Herein, we present a mitochondria …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Prolonged treatment with the oxazolidinone linezolid is associated with myelosuppression,
lactic acidosis, and neuropathies, toxicities likely caused by impairment of mitochondrial …

MicroRNA-210 (miR-210) induction is a virtually constant feature of the hypoxic response in
both normal and transformed cells, regulating several key aspects of cardiovascular …

Mitotane, 1, 1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane (o, p'-DDD) is the most
effective medical therapy for adrenocortical carcinoma but its molecular mechanism of action …

Background: The incidence of cardiovascular disease is higher in HIV-positive (HIV+)
patients than it is in the average population, and combination antiretroviral therapy (cART) is …

Mitochondria represent a possible drug target with unexplored therapeutic and toxicological
potential. The possibility was suggested that antidepressants, mood stabilizers and other …

Increased metabolic stress during early lactation results in damage of mitochondria and
inflammatory responses in bovine mammary epithelial cells, both of which could be …