Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox

P Dimitri, N Bishop, JS Walsh, R Eastell - Bone, 2012 - Elsevier
With the rise in obesity worldwide, an important debate has developed as to whether excess
fat has a detrimental or protective effect on skeletal health in children and adults. Obese …

Association between body composition and bone mineral density in children and adolescents: a systematic review and meta-analysis

KL Deng, WY Yang, JL Hou, H Li, H Feng… - International Journal of …, 2021 - mdpi.com
Background: Bone mass acquisition during growth is a major determinant of the risk of
developing osteoporosis later in life. Body composition is an anthropometric determinant of …

Fat and bone in children: differential effects of obesity on bone size and mass according to fracture history

P Dimitri, JK Wales, N Bishop - Journal of Bone and Mineral …, 2010 - academic.oup.com
Fat mass predicts bone accrual in prepubertal children, but obese children have increased
fracture risk. We hypothesised that bone size and mass would vary according to prior …

Adipokines, bone-derived factors and bone turnover in obese children; evidence for altered fat-bone signalling resulting in reduced bone mass

P Dimitri, JK Wales, N Bishop - Bone, 2011 - Elsevier
Obese children, particularly those who have fractured, have reduced body size-adjusted
total body and regional bone mass. We performed an observational cross-sectional cohort …

Assessing bone health in children and adolescents

MA Levine - Indian journal of endocrinology and metabolism, 2012 - journals.lww.com
During normal childhood and adolescence, the skeleton undergoes tremendous change.
Utilizing the processes of modeling and remodeling, the skeleton acquires its adult …

Relationship of total body fat mass to weight-bearing bone volumetric density, geometry, and strength in young girls

JN Farr, Z Chen, JR Lisse, TG Lohman, SB Going - Bone, 2010 - Elsevier
Understanding the influence of total body fat mass (TBFM) on bone during the peri-pubertal
years is critical for the development of future interventions aimed at improving bone strength …

[HTML][HTML] Overweight children have a greater proportion of fat mass relative to muscle mass in the upper limbs than in the lower limbs: implications for bone strength at …

G Ducher, SL Bass, GA Naughton, P Eser… - The American journal of …, 2009 - Elsevier
Background: The influence of adiposity on upper-limb bone strength has rarely been studied
in children, despite the high incidence of forearm fractures in this population. Objective: The …

Bone size and bone strength are increased in obese male adolescents

S Vandewalle, Y Taes, M Van Helvoirt… - The Journal of …, 2013 - academic.oup.com
Context: Controversy exists on the effect of obesity on bone development during puberty.
Objective: Our objective was to determine differences in volumetric bone mineral density …

Dual effect of adipose tissue on bone health during growth

HT Viljakainen, M Pekkinen, E Saarnio, H Karp… - Bone, 2011 - Elsevier
Recent studies suggest association between body fat and childhood bone health, although
conflicting findings have also been reported. The aim of the present study was to examine …

[HTML][HTML] Relative importance of lean and fat mass on bone mineral density in Iranian children and adolescents

M Jeddi, MH Dabbaghmanesh, GR Omrani… - … of endocrinology and …, 2015 - ncbi.nlm.nih.gov
Background: Body weight is made up of lean and fat mass and both are involved in growth
and development. Impression of these two components in bone density accrual has been …