On the nature of selenium toxicity and carcinostatic activity

JE Spallholz - Free Radical Biology and Medicine, 1994 - Elsevier
Selenium toxicity was first confirmed in 1933 to occur in livestock that consumed plants of
the genus Astragalus, Xylorrhiza, Oonopsis, and Stanleya in the western regions of the …

Selenium and its relationship to cancer: an update

PD Whanger - British journal of nutrition, 2004 - cambridge.org
Selenomethionine (Semet) is the major seleno-compound in cereal grains and enriched
yeast whereas Se-methylselenocysteine (SeMCYS) is the major seleno-compound in Se …

[HTML][HTML] Chemopreventive agents: selenium

GF Combs Jr, WP Gray - Pharmacology & therapeutics, 1998 - Elsevier
The element selenium (Se) was recognized only 40 years ago as being essential in the
nutrition of animals and humans. It is recognized as being an essential component of a …

[图书][B] The role of selenium in nutrition.

GFJ Combs, SB Combs - 1986 - cabidigitallibrary.org
This book contains 11 chapters entitled: chemical aspects of selenium; selenium in the
environment; selenium in foods and feeds; the biological availability of selenium in foods …

The protective role of selenium on genetic damage and on cancer

K El-Bayoumy - … Research/Fundamental and Molecular Mechanisms of …, 2001 - Elsevier
Collectively, results from epidemiologic studies, laboratory bioassays, and human clinical
intervention trials clearly support a protective role of selenium against cancer development …

Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds

R Sinha, K El-Bayoumy - Current cancer drug targets, 2004 - ingentaconnect.com
Epidemiological studies, preclinical investigations and clinical intervention trials support the
role of selenium compounds as potent cancer chemopreventive agents; the dose and the …

An analysis of cancer prevention by selenium

GF Combs Jr, LC Clark, BW Turnbull - Biofactors, 2001 - Wiley Online Library
The nutritional functions of selenium (Se) are recognized as being due to a number of Se‐
containing proteins. It is not clear, however, whether any of these function in the anti …

Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts

S Cao, FA Durrani, YM Rustum - Clinical Cancer Research, 2004 - AACR
Purpose: Studies were carried out in athymic nude mice bearing human squamous cell
carcinoma of the head and neck (FaDu and A253) and colon carcinoma (HCT-8 and HT-29) …

[HTML][HTML] Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase.

M Björnstedt, S Kumar, A Holmgren - Journal of Biological Chemistry, 1992 - Elsevier
Selenium compounds like selenite (SeO3 (2-) may form a covalent adduct with glutathione
(GSH) in the form of selenodiglutathione (GS-Se-SG), which is assumed to be important in …

Selenium and immune responses

L Kiremidjian-Schumacher, G Stotzky - Environmental Research, 1987 - Elsevier
Selenium (Se) affects all components of the immune system, ie, the development and
expression of nonspecific, humoral, and cell-mediated responses. In general, a deficiency in …