Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies;
however, insufficient tumor immunogenicity and the immunosuppressive tumor …

The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with
a dramatic decline in physical activity are the alleged main causes for this pandemic. While …

Thermoregulation is the maintenance of a relatively constant core body temperature.
Humans normally maintain a body temperature at 37 C, and maintenance of this relatively …

Brown adipose tissue (BAT) is known to function in the dissipation of chemical energy in
response to cold or excess feeding, and also has the capacity to modulate energy balance …

Resveratrol is one of the most widely studied polyphenols and it has been assigned a
plethora of metabolic effects with potential health benefits. Given its low bioavailability and …

Obesity develops when energy intake exceeds energy expenditure. Promoting brown
adipose tissue formation and function increases energy expenditure and hence may …

All homeotherms use thermogenesis to maintain their core body temperature, ensuring that
cellular functions and physiological processes can continue in cold environments,,. In the …

Metabolic disorders are characterized by the inability to properly use and/or store energy.
The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through …