Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

Although psychiatric drug withdrawal syndromes have been recognized since the 1950s–
recent studies confirm antidepressant withdrawal syndrome incidence upwards of 40 …

The process of stopping antipsychotics may be causally related to relapse, potentially linked
to neuroadaptations that persist after cessation, including dopaminergic hypersensitivity …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1),
have been associated with a spectrum of epilepsies and neurodevelopmental disorders …

Recent research has demonstrated the potential of psychedelic therapy for mental health
care. However, the psychological experience underlying its therapeutic effects remains …

Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

In England, the prescribing of antidepressants, primarily the newer generation
antidepressant classes, has steadily increased over recent years. There is ongoing debate …

Background: Tapering strips facilitate antidepressant discontinuation, allowing for
personalised titration of discontinuation to the intensity of withdrawal. A tapering strip …

Background Public Health England recently called for the establishment of services to help
people to safely stop prescribed drugs associated with dependence and withdrawal …