With better serum UMOD detection assays the extent of different functions for UMOD is still
expanding. Urinary UMOD regulates different tubular ion channels and cotransporters …

Aims Uromodulin is produced exclusively in the kidney and secreted into both urine and
blood. Serum levels of uromodulin are correlated with kidney function and reduced in …

Background Gdf15 encodes a TGF-β superfamily member that is rapidly activated in
response to stress in multiple organ systems, including the kidney. However, there has been …

Background: The association of uromodulin and hypertension has been observed in clinical
studies, but not proven by a causal relationship. We conducted a two-sample Mendelian …

Pyruvate kinase M2 (PKM2), as the terminal and last rate-limiting enzyme of the glycolytic
pathway, is an ideal enzyme for regulating metabolic phenotype. PKM2 tetramer activation …

Uromodulin (UMOD) is a glycoprotein that is selectively expressed on the epithelial cells of
the thick ascending limb of Henle's loop and the early distal renal tubule. The present study …

Serum uromodulin (sUmod) shows a strong direct correlation with eGFR in patients with
impaired kidney function and an inverse association with mortality. However, there are …

Uromodulin (UMOD) is a complex glycoprotein that is to a large extent secreted by renal
epithelial cells lining the thick ascending limb (TAL) and is the most abundant protein found …