The impact of the immune system on lung injury and regeneration in COPD
TS Kapellos, TM Conlon, AÖ Yildirim… - European Respiratory …, 2023 - Eur Respiratory Soc
COPD is a devastating respiratory condition that manifests via persistent inflammation,
emphysema development and small airway remodelling. Lung regeneration is defined as …
emphysema development and small airway remodelling. Lung regeneration is defined as …
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
W Tao, Z Yu, JDJ Han - Cell Metabolism, 2024 - cell.com
Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …
challenges for studying and targeting senescent cells. We present here a machine learning …
Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …
Aging in chronic lung disease: will anti-aging therapy be the key to the cure?
W Wang, K Zhou, L Wang, Q Qin, H Liu, L Qin… - European Journal of …, 2024 - Elsevier
Chronic lung disease is the third leading cause of death globally, imposing huge burden of
death, disability and healthcare costs. However, traditional pharmacotherapy has relatively …
death, disability and healthcare costs. However, traditional pharmacotherapy has relatively …
Differences in mortality among patients with asthma and COPD hospitalized with COVID-19
Background It remains unclear whether patients with asthma and/or chronic obstructive
pulmonary disease (COPD) are at increased risk for severe coronavirus disease 2019 …
pulmonary disease (COPD) are at increased risk for severe coronavirus disease 2019 …
[HTML][HTML] Identification of related-genes of T cells in lung tissue of chronic obstructive pulmonary disease based on bioinformatics and experimental validation
T Xue, F Dong, J Gao, X Zhong - Scientific Reports, 2024 - nature.com
T cells are one of the main cell types shaping the immune microenvironment in chronic
obstructive pulmonary disease (COPD). They persist andplay cytotoxic roles. The purpose of …
obstructive pulmonary disease (COPD). They persist andplay cytotoxic roles. The purpose of …
Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes
Y Wu, Y Gou, T Wang, P Li, Y Li, X Lu, W Li… - International …, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) poses a significant health threat
characterized by lung inflammation primarily triggered by pulmonary monocytes. Despite the …
characterized by lung inflammation primarily triggered by pulmonary monocytes. Despite the …
[HTML][HTML] Exploring Molecular Mechanisms and Biomarkers in COPD: An Overview of Current Advancements and Perspectives
CL Li, SF Liu - International Journal of Molecular Sciences, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) plays a significant role in global morbidity
and mortality rates, typified by progressive airflow restriction and lingering respiratory …
and mortality rates, typified by progressive airflow restriction and lingering respiratory …
RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD
W Shen, W Wei, S Wang, X Yang, R Wang, H Tian - Gene, 2024 - Elsevier
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is characterized by
high morbidity, disability, and mortality rates worldwide. RNA-binding proteins (RBPs) might …
high morbidity, disability, and mortality rates worldwide. RNA-binding proteins (RBPs) might …
Computational Deconvolution of Cell Type-Specific Gene Expression in COPD and IPF Lungs Reveals Disease Severity Associations
Rationale Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis
(IPF) are debilitating diseases associated with divergent histopathological changes in the …
(IPF) are debilitating diseases associated with divergent histopathological changes in the …