The impact of the immune system on lung injury and regeneration in COPD

TS Kapellos, TM Conlon, AÖ Yildirim… - European Respiratory …, 2023 - Eur Respiratory Soc
COPD is a devastating respiratory condition that manifests via persistent inflammation,
emphysema development and small airway remodelling. Lung regeneration is defined as …

Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators

W Tao, Z Yu, JDJ Han - Cell Metabolism, 2024 - cell.com
Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung

AB Villaseñor-Altamirano, D Jain, Y Jeong… - American Journal of …, 2023 - atsjournals.org
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …

Aging in chronic lung disease: will anti-aging therapy be the key to the cure?

W Wang, K Zhou, L Wang, Q Qin, H Liu, L Qin… - European Journal of …, 2024 - Elsevier
Chronic lung disease is the third leading cause of death globally, imposing huge burden of
death, disability and healthcare costs. However, traditional pharmacotherapy has relatively …

Differences in mortality among patients with asthma and COPD hospitalized with COVID-19

Y Liu, H Rajeevan, M Simonov, S Lee… - The Journal of Allergy …, 2023 - Elsevier
Background It remains unclear whether patients with asthma and/or chronic obstructive
pulmonary disease (COPD) are at increased risk for severe coronavirus disease 2019 …

[HTML][HTML] Identification of related-genes of T cells in lung tissue of chronic obstructive pulmonary disease based on bioinformatics and experimental validation

T Xue, F Dong, J Gao, X Zhong - Scientific Reports, 2024 - nature.com
T cells are one of the main cell types shaping the immune microenvironment in chronic
obstructive pulmonary disease (COPD). They persist andplay cytotoxic roles. The purpose of …

Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes

Y Wu, Y Gou, T Wang, P Li, Y Li, X Lu, W Li… - International …, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) poses a significant health threat
characterized by lung inflammation primarily triggered by pulmonary monocytes. Despite the …

[HTML][HTML] Exploring Molecular Mechanisms and Biomarkers in COPD: An Overview of Current Advancements and Perspectives

CL Li, SF Liu - International Journal of Molecular Sciences, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) plays a significant role in global morbidity
and mortality rates, typified by progressive airflow restriction and lingering respiratory …

RNA-binding protein AZGP1 inhibits epithelial cell proliferation by regulating the genes of alternative splicing in COPD

W Shen, W Wei, S Wang, X Yang, R Wang, H Tian - Gene, 2024 - Elsevier
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is characterized by
high morbidity, disability, and mortality rates worldwide. RNA-binding proteins (RBPs) might …

Computational Deconvolution of Cell Type-Specific Gene Expression in COPD and IPF Lungs Reveals Disease Severity Associations

MH Ryu, JH Yun, K Kim, M Gentili, A Ghosh, F Sciurba… - medRxiv, 2024 - medrxiv.org
Rationale Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis
(IPF) are debilitating diseases associated with divergent histopathological changes in the …