Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …

ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the
plasma membrane of diverse cells, which contributes to cellular drug resistance and …

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that becomes activated at the lysosome in response to nutrient cues. Here, we …

The calcium-sensing receptor (CaSR), a cell-surface sensor for Ca2+, is the master
regulator of calcium homeostasis in humans and is the target of calcimimetic drugs for the …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …

Controlled distribution of lipids across various cell membranes is crucial for cell homeostasis
and regulation. We developed an imaging method that allows simultaneous in situ …