Battle of the biopsies: role of tissue and liquid biopsy in hepatocellular carcinoma

BM Lehrich, J Zhang, SP Monga, R Dhanasekaran - Journal of Hepatology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) diagnosis and management have undergone significant
improvements in recent years. With the introduction of immunotherapy-based combination …

Molecular genealogy of metabolic-associated hepatocellular carcinoma

T Kodama, T Takehara - Seminars in Liver Disease, 2024 - thieme-connect.com
This review examines the latest epidemiological and molecular pathogenic findings of
metabolic-associated hepatocellular carcinoma (HCC). Its increasing prevalence is a …

Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma

H Suzuki, H Iwamoto, T Tanaka, T Sakaue… - Hepatology …, 2024 - Springer
Background & aims Combination immunotherapy refers to the use of immune checkpoint
inhibitors (ICI) and molecular-targeted agents (MTA), which have recently been approved for …

Minichromosome maintenance protein family member 6 mediates hepatocellular carcinoma progression by recruiting UBE3A to induce P53 ubiquitination

X Zhang, S Bian, Y Ni, L Zhou, C Yang, C Zhang… - International Journal of …, 2023 - Elsevier
With limited therapeutic options for hepatocellular carcinoma (HCC), it is of great
significance to investigate the underlying mechanisms and identifying tumor drivers. MCM6 …

Precision treatment in advanced hepatocellular carcinoma

X Yang, C Yang, S Zhang, H Geng, AX Zhu… - Cancer Cell, 2024 - cell.com
The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

Emerging therapies targeting growth factors in hepatocellular carcinoma

SM Ruff, TM Pawlik - Expert Opinion on Pharmacotherapy, 2024 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) is a primary liver cancer that commonly arises
in the background of chronic liver inflammation and/or cirrhosis. Chronic liver inflammation …

Chemoprevention in hepatocellular carcinoma

H Suzuki, CH Ng, DJH Tan, M Teng… - Current Hepatology …, 2023 - Springer
Abstract Purpose of Review The number of deaths due to hepatocellular carcinoma (HCC)
continues to rise. Chemoprevention may be a useful strategy to prevent HCC. Recent …

The translation of oncogenic mRNAs regulated by pseudouridylation: A new player in hepatocellular carcinoma

H Nakagawa, A Lin - Hepatology, 2024 - journals.lww.com
In recent years, novel drugs for hepatocellular carcinoma (HCC) have been consistently
approved, leading to a significant expansion of treatment options. However, the targets …

[HTML][HTML] Primary liver cancer spectrum: current knowledge and the next steps

MS Rezaee-Zavareh, EK Koltsova… - … Surgery and Nutrition, 2024 - ncbi.nlm.nih.gov
Correspondence to: Ju Dong Yang, MD. Karsh Division of Gastroenterology and
Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Comprehensive …

Matrisomic characterization of HCC to inform individualized patient management

H Kanzaki, C Katz, Y Hoshida - Hepatology, 2023 - journals.lww.com
Rapid development of molecular-targeted and immunebased agents has substantially
expanded clinically available therapeutic options in HCC.[1] However, the limited response …