The roles of serotonin in neuropsychiatric disorders
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …
[PDF][PDF] Neuromodulation of attention
A Thiele, MA Bellgrove - Neuron, 2018 - cell.com
Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic
and neuropsychiatric disorders. Although years of research indicates that distinct …
and neuropsychiatric disorders. Although years of research indicates that distinct …
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine
Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation
antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce …
antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce …
Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity
MD Underwood, SA Kassir, MJ Bakalian… - Translational …, 2018 - nature.com
Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD)
and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we …
and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we …
A Short Synthesis of Ergot Alkaloids and Evaluation of the 5-HT1/2 Receptor Selectivity of Lysergols and Isolysergols
Key transformations in a four-step synthesis of the ergot alkaloid scaffold include a novel
cesium carbonate-mediated hydrogen autotransfer alkylation to generate the C (3)–C (4) …
cesium carbonate-mediated hydrogen autotransfer alkylation to generate the C (3)–C (4) …
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders
R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
Atypical antipsychotics attenuate MK801-induced social withdrawal and hyperlocomotion in the RHA rat model of schizophrenia-relevant features
D Sampedro-Viana, T Cañete, F Sanna, I Oliveras… - …, 2023 - Springer
Rationale The administration of NMDA receptor (NMDAR) antagonists constitutes a widely
used model that produce both positive (eg, hyperactivity) and negative (eg, social …
used model that produce both positive (eg, hyperactivity) and negative (eg, social …
Interclass GPCR heteromerization affects localization and trafficking
Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …
Psychedelics as novel therapeutics in Alzheimer's disease: rationale and potential mechanisms
A Garcia-Romeu, S Darcy, H Jackson, T White… - Disruptive …, 2021 - Springer
Abstract Serotonin 2A receptor (5-HT2AR) agonist “classic psychedelics” are drawing
increasing interest as potential mental health treatments. Recent work suggests …
increasing interest as potential mental health treatments. Recent work suggests …
Medial prefrontal cortical control of reward‐and aversion‐based behavioral output: Bottom‐up modulation
How does the brain guide our actions? This is a complex issue, where the medial prefrontal
cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and …
cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and …