SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19) …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to …

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …

Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening
disease, typically in patients with no previous history of severe viral illness. Autosomal …

Autoimmune Polyendocrine Syndromes Autoimmune polyendocrine syndromes comprise a
diverse group of clinical entities involving functional impairment of multiple endocrine glands …