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The drug development is generally arduous, costly, and success rates are low. Thus, the
identification of drug-target interactions (DTIs) has become a crucial step in early stages of …

Although equilibrium competitive radioligand binding studies are often used to characterize
hormone and neurotransmitter receptors, the kinetics of such experiments have not been …

Steroids may rapidly alter neuronal function and behavior through poorly characterized,
direct actions on neuronal membranes. The membrane-bound receptors mediating these …

The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor
involved in the regulation of several genes, including those for xenobiotic-metabolizing …

The effects of catecholamines in the central and peripheral nervous systems appear to be
mediated through interactions with 2 major classes of receptor: α-adrenoceptors and β …

To study the molecular basis of differences in the insecticidal spectrum of Bacillus
thuringiensisδ‐endotoxins, we have performed binding studies with three δ‐endotoxins on …

The substituted benzamide drug raclopride,[((-)-(S)-3, 5-dichloro-N-((1-ethyl-2-pyrrolidinyl)
methyl)-6-methoxy-salicylamide tartrate; FLA 870 (-); A40664] was shown to be a potent and …

We have developed two independent methods to measure equilibrium binding of inhibitors
to membrane-bound and partially purified NADH: ubiquinone oxidoreductase (complex I) to …

A cDNA clone coding for a functional human prostanoid FP receptor has been isolated from
a uterus cDNA library. The human FP receptor consists of 359 amino acid residues with a …