Severe sepsis is almost invariably associated with systemic activation of coagulation. There
is ample evidence that demonstrates a wide-ranging cross-talk between hemostasis and …

Platelets are small anucleate cell fragments that circulate in blood playing crucial role in
managing vascular integrity and regulating hemostasis. Platelets are also involved in the …

In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

Thrombocytopenia is the most common hematological abnormality encountered in patients
with chronic liver disease (CLD). In addition to being an indicator of advanced disease and …

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Toll-like receptors (TLRs) play a critical role in stimulating innate immunity by recognizing
pathogen-associated molecular patterns (PAMPs) on invading microorganisms. Platelets …

The platelet, a fascinating anucleate cell, is critically important for haemostasis. Platelet
transfusions have greatly reduced the incidence of major haemorrhagic complications …

Objectives: To examine platelet count and indices (mean platelet volume (MPV) and platelet
distribution width (PDW)) in severe sepsis. Methods: Patients with criteria for sepsis at a first …

Heparin-induced thrombocytopenia (HIT) is a potentially devastating immune mediated
adverse drug reaction caused by the emergence of antibodies that activate platelets in the …

Background Coronavirus infectious disease 2019 (COVID-19) has developed into a global
pandemic. It is essential to investigate the clinical characteristics of COVID-19 and uncover …