Membranous nephropathy: new pathogenic mechanisms and their clinical implications
E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …
[HTML][HTML] Membranous nephropathy
P Ronco, L Beck, H Debiec, FC Fervenza… - Nature reviews Disease …, 2021 - nature.com
Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …
[HTML][HTML] Rituximab in membranous nephropathy
Membranous nephropathy is the most common cause of primary nephrotic syndrome among
adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in a …
adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in a …
[HTML][HTML] Netrin G1 is a novel target antigen in primary membranous nephropathy
L Reinhard, M Machalitza, T Wiech… - Journal of the …, 2022 - journals.lww.com
Background Primary membranous nephropathy (MN) is caused by circulating
autoantibodies binding to antigens on the podocyte surface. PLA 2 R1 is the main target …
autoantibodies binding to antigens on the podocyte surface. PLA 2 R1 is the main target …
[HTML][HTML] Advances in the management of primary membranous nephropathy and rituximab-refractory membranous nephropathy
M Teisseyre, M Cremoni, S Boyer-Suavet… - Frontiers in …, 2022 - frontiersin.org
Primary membranous nephropathy (pMN) is an auto-immune disease characterized by auto-
antibodies targeting podocyte antigens resulting in activation of complement and damage to …
antibodies targeting podocyte antigens resulting in activation of complement and damage to …
Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice
NM Tomas, S Dehde, C Meyer-Schwesinger… - Kidney international, 2023 - Elsevier
Antibody-mediated autoimmune pathologies like membranous nephropathy are difficult to
model, particularly in the absence of local target antigen expression in model organisms …
model, particularly in the absence of local target antigen expression in model organisms …
[HTML][HTML] Idiopathic membranous nephropathy: glomerular pathological pattern caused by extrarenal immunity activity
W Liu, C Gao, Z Liu, H Dai, Z Feng, Z Dong… - Frontiers in …, 2020 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is a pathological pattern of glomerular damage
caused by an autoimmune response. Immune complex deposition, thickness of glomerular …
caused by an autoimmune response. Immune complex deposition, thickness of glomerular …
Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch
M Fresquet, MP Lockhart-Cairns… - Proceedings of the …, 2022 - National Acad Sciences
Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
The management of membranous nephropathy—an update
F Caravaca-Fontán… - Nephrology Dialysis …, 2022 - academic.oup.com
In recent decades, several important advances have taken place in the understanding of the
pathogenesis underlying membranous nephropathy (MN) that have sparked renewed …
pathogenesis underlying membranous nephropathy (MN) that have sparked renewed …