Case fatality rates for severe malaria remain high even in the best clinical settings because
antimalarial drugs act against the parasite without alleviating life-threatening inflammation …

Babesia rossi infection causes a severe inflammatory response in the dog, which is the
result of the balance between pro-and anti-inflammatory cytokine secretion. The aim of this …

The role of early to intermediate Plasmodium falciparum-induced cellular responses in the
development of clinical immunity to malaria is not well understood, and such responses …

Despite intense research, malaria still is the one of the most devastating diseases killing
more people than any other parasitic infection. In an attempt to control the infection, the host …

Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful
model to define genetic determinants that regulate the development of cerebral malaria …

Background. Severe malaria (SM) is associated with high levels of cytokines such as tumor
necrosis factor (TNF), interleukin 1 (IL-1), and interleukin 6 (IL-6). The role of chemokines is …

Background In individuals living in malaria-endemic regions, parasitaemia thresholds for the
onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate …

Despite significant progress in combating malaria in recent years the burden of severe
disease and death due to Plasmodium infections remains a global public health concern …

Host susceptibility to Plasmodium falciparum infection is central for improved understanding
of malaria in human populations. Red blood cell (RBC) polymorphisms have been proposed …

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction
of parasites with endothelial protein C receptors and high parasite biomass have recently …