The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

The pattern recognition receptor, RAGE (receptor for advanced glycation endproducts),
propagates cellular dysfunction in several inflammatory disorders and diabetes. Here we …

Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen,
plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators …

Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration
of leukocytes to sites of injury requires their exit from the blood and migration across …

Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma
patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds …

Plasmin, one of the most potent and reactive serine proteases, is involved in various
physiological processes, including embryo development, thrombolysis, wound healing and …

The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer
progression, presumably via mediating extracellular matrix degradation and tumor cell …

ABSTRACT Plasminogen activator inhibitor 1 (PAI‐1) is believed to control proteolytic
activity and cell migration during angiogenesis. We previously demonstrated in vivo that this …

Inflammation resolution is an active process that functions to restore tissue homeostasis. The
participation of the plasminogen (Plg)/plasmin (Pla) system in the productive phase of …