Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
Selective vulnerability in neurodegenerative diseases
Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …
usually take them for granted. The first is that the pathology associated with the disease only …
The future of stem cell therapies for Parkinson disease
M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
[HTML][HTML] Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use
Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …
medicine, including the development of cell replacement paradigms for the treatment of …
Review of the current trends in clinical trials involving induced pluripotent stem cells
JY Kim, Y Nam, YA Rim, JH Ju - Stem cell reviews and reports, 2022 - Springer
In 2006, the induced pluripotent stem cell (iPSC) was presented to the world, paving the way
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …
Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening
MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Cells, 2021 - mdpi.com
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …
to the field of regenerative medicine, paving way for identifying the true potential of human …
Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis
J Deinsberger, D Reisinger, B Weber - NPJ Regenerative medicine, 2020 - nature.com
Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to
regenerate or replace functionally impaired tissues. Since the introduction of the induced …
regenerate or replace functionally impaired tissues. Since the introduction of the induced …
Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation
Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain
dopaminergic (DA) neurons for cell replacement therapy for Parkinson's disease. However …
dopaminergic (DA) neurons for cell replacement therapy for Parkinson's disease. However …
Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …