Although adrenal steroid receptors are distributed widely throughout the central nervous
system, specific limbic and cortical regions targeted by stress hormones play a key role in …

Oxidative stress is believed to be the cause of cell death in multiple disorders of the brain,
including perinatal hypoxia/ischemia. Glutamate, cystine deprivation, homocysteic acid, and …

Oxidative stress can induce cytotoxicity in neurons, which plays an important role in the
etiology of neuronal damage and degeneration. This study sought to determine the cellular …

Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine
dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as …

The extracellular signal regulated protein kinases (ERK1/2) are essential for normal
development and functional plasticity of the central nervous system. However, a growing …

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic nigrostriatal
neurons, which leads to disabling motor disturbances. Sulforaphane (SFN), found in …

Oxidative stress is implicated in the pathogenesis of neuronal degenerative diseases.
Oxidative stress has been shown to activate extracellular signal-regulated kinases (ERK) …

Ferroptosis is a newly identified regulated form of cell death, which is thought to play a major
role in neurodegenerative diseases. In this review, we discuss recent studies elucidating the …

Sustained activation of poly (ADP-ribose) polymerase-1 (PARP-1) and extracellular signal-
regulated kinases 1/2 (ERK1/2) both promote neuronal death. Here we identify a direct link …

Reactive oxygen species including H2O2 activate an array of intracellular signalling
cascades that are closely associated with cell death and cell survival pathways. The human …