Understanding nucleosome dynamics and their links to gene expression and DNA replication
WKM Lai, BF Pugh - Nature reviews Molecular cell biology, 2017 - nature.com
Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
A high-resolution protein architecture of the budding yeast genome
The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …
integrity and gene regulation is not well defined. Here we use chromatin …
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors
Chromatin remodelling complexes evict, slide, insert or replace nucleosomes, which
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
[HTML][HTML] Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
GJ Narlikar, R Sundaramoorthy, T Owen-Hughes - Cell, 2013 - cell.com
Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …
small space and a means to package the same genetic material in different chromatin states …
Determinants of nucleosome positioning
Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …
Here we review the dominant patterns of nucleosome positioning that have been observed …
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
Prostate cancers remain indolent in the majority of individuals but behave aggressively in a
minority,. The molecular basis for this clinical heterogeneity remains incompletely …
minority,. The molecular basis for this clinical heterogeneity remains incompletely …
Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states
C Kadoch, RT Williams, JP Calarco, EL Miller… - Nature …, 2017 - nature.com
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF)
complexes has a critical role in both development and disease. Mutations in the genes …
complexes has a critical role in both development and disease. Mutations in the genes …
Genomic nucleosome organization reconstituted with pure proteins
N Krietenstein, M Wal, S Watanabe, B Park… - Cell, 2016 - cell.com
Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …
their individual contributions are obfuscated by the complex in vivo milieu of factor …
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …