Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

[PDF][PDF] Oxidative stress and inflammatory markers in prediabetes and diabetes.

K Luc, A Schramm-Luc, TJ Guzik… - Journal of Physiology & …, 2019 - researchgate.net
Prediabetes is a state of elevated plasma glucose in which the threshold for diabetes has
not yet been reached and can predispose to the development of type 2 diabetes and …

[PDF][PDF] Targeting ferroptosis to iron out cancer

B Hassannia, P Vandenabeele, TV Berghe - Cancer cell, 2019 - cell.com
One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

[HTML][HTML] Iron in infection and immunity

M Nairz, G Weiss - Molecular Aspects of Medicine, 2020 - Elsevier
Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

Transcriptional regulation by Nrf2

C Tonelli, IIC Chio, DA Tuveson - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Prevalence of exposure of heavy metals and their impact on health consequences

K Rehman, F Fatima, I Waheed… - Journal of cellular …, 2018 - Wiley Online Library
Even in the current era of growing technology, the concentration of heavy metals present in
drinking water is still not within the recommended limits as set by the regulatory authorities in …

Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

QM Chen - Free Radical Biology and Medicine, 2022 - Elsevier
Myocardial infarction is the most common form of acute coronary syndrome. Blockage of a
coronary artery due to blood clotting leads to ischemia and subsequent cell death in the form …

Drug induced liver injury: an update

M Garcia-Cortes, M Robles-Diaz, C Stephens… - Archives of …, 2020 - Springer
Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of
medications, illegal drugs, herbal products or dietary supplements. It occurs in susceptible …

Unhealthy lifestyle and gut dysbiosis: a better understanding of the effects of poor diet and nicotine on the intestinal microbiome

JE Martinez, DD Kahana, S Ghuman… - Frontiers in …, 2021 - frontiersin.org
The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention.
Bidirectional communication between gut microbes and the host can impact numerous …

Redox biology of respiratory viral infections

OA Khomich, SN Kochetkov, B Bartosch, AV Ivanov - Viruses, 2018 - mdpi.com
Respiratory viruses cause infections of the upper or lower respiratory tract and they are
responsible for the common cold—the most prevalent disease in the world. In many cases …