Myofibroblasts are characterized by their expression of α-smooth muscle actin, their
enhanced contractility when compared to normal fibroblasts and their increased synthetic …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …

Increased collagen expression in tumors is associated with increased risk of metastasis, and
triple-negative breast cancer (TNBC) has the highest propensity to develop distant …

Abstract Development of an effective treatment against advanced tumors remains a major
challenge for cancer immunotherapy. We have previously developed a potent mannose …

Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing
collagen and extracellular matrix, the structural framework for tissues, helping to bring …

Cutaneous melanoma (CM) is a highly aggressive and drug resistant solid tumor, showing
an impressive metabolic plasticity modulated by oncogenic activation. In particular …

Cancer-associated fibroblasts (CAFs) not only support tumorigenesis and tumor metastasis
by reciprocal cellular cross-talk with cancer cells, but also remodel the extracellular matrix …

Our understanding of how human skin cells differ according to anatomical site and tumour
formation is limited. To address this, we have created a multiscale spatial atlas of healthy …