β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
[HTML][HTML] BRAF V600-mutated metastatic melanoma and targeted therapy resistance: an update of the current knowledge
L Florent, C Saby, F Slimano, H Morjani - Cancers, 2023 - mdpi.com
Simple Summary Metastatic melanoma is the most lethal skin cancer due to its high
metastatic potential and resistance to treatment. The advent of targeted therapies has …
metastatic potential and resistance to treatment. The advent of targeted therapies has …
[HTML][HTML] Current insights and progress in the clinical management of head and neck cancer
Simple Summary Head and neck cancer (HNC) incidence has been steadily increasing
since the 1990s. While the multimodal treatment approach for localized HNC is well …
since the 1990s. While the multimodal treatment approach for localized HNC is well …
[HTML][HTML] Current treatment of melanoma brain metastases
A Nowacka, A Fajkiel-Madajczyk, J Ohla… - Cancers, 2023 - mdpi.com
Simple Summary Melanoma has the highest mortality rate of all skin cancers and its
prognosis is worsened by metastasis to the brain. Before discovering new treatments for …
prognosis is worsened by metastasis to the brain. Before discovering new treatments for …
[HTML][HTML] Determination of some isoquinoline alkaloids in extracts obtained from selected plants of the Ranunculaceae, Papaveraceae and Fumarioideae families by …
J Misiurek, T Plech, B Kaproń, A Makuch-Kocka… - Molecules, 2023 - mdpi.com
Alkaloids are heterocyclic bases with widespread occurrence in nature. Plants are rich and
easily accessible sources of them. Most isoquinoline alkaloids have cytotoxic activity for …
easily accessible sources of them. Most isoquinoline alkaloids have cytotoxic activity for …
[HTML][HTML] Efficacy and Safety of Rechallenge with BRAF/MEK Inhibitors in Advanced Melanoma Patients: A Systematic Review and Meta-Analysis
Simple Summary Approximately 50% of patients with melanoma harbor a BRAF mutation
and are eligible for targeted therapy with BRAF/MEK inhibitors (BRAFi/MEKi). Despite a …
and are eligible for targeted therapy with BRAF/MEK inhibitors (BRAFi/MEKi). Despite a …
[HTML][HTML] Photodynamic Activity of TMPyP4/TiO2 Complex under Blue Light in Human Melanoma Cells: Potential for Cancer-Selective Therapy
The combination of TiO2 nanoparticles (NPs) and photosensitizers (PS) may offer significant
advantages in photodynamic therapy (PDT) of melanoma, such as improved cell …
advantages in photodynamic therapy (PDT) of melanoma, such as improved cell …
[HTML][HTML] A review of advanced cutaneous melanoma therapies and their mechanisms, from immunotherapies to lysine histone methyl transferase inhibitors
RS de Oliveira Filho, DA de Oliveira, MM Nisimoto… - Cancers, 2023 - mdpi.com
Simple Summary Advanced cutaneous melanoma is the most aggressive type of skin cancer
and has variable rates of treatment response. Currently, there are some classes of …
and has variable rates of treatment response. Currently, there are some classes of …
[HTML][HTML] Pterostilbene-mediated inhibition of cell proliferation and cell death induction in amelanotic and melanotic melanoma
J Wawszczyk, K Jesse, M Kapral - International Journal of Molecular …, 2023 - mdpi.com
Melanoma is one of the fastest-growing cancers worldwide. Treatment of advanced
melanoma is very difficult; therefore, there is growing interest in the identification of new …
melanoma is very difficult; therefore, there is growing interest in the identification of new …
[HTML][HTML] Daphnetin, a coumarin with anticancer potential against human melanoma: in vitro study of its effective combination with selected cytostatic drugs
P Wróblewska-Łuczka, A Góralczyk, JJ Łuszczki - Cells, 2023 - mdpi.com
(1) The treatment of metastatic or drug-resistant melanoma is still a significant therapeutic
problem. The aim of this study was to evaluate the anticancer potential of daphnetin (7, 8 …
problem. The aim of this study was to evaluate the anticancer potential of daphnetin (7, 8 …