The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies
implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

Despite significant strides made in understanding the pathophysiology of high-grade
gliomas over the past two decades, most patients succumb to these neoplasias within two …

The progression of glioblastomas is associated with a variety of neurological impairments,
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …

Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to
control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 …

Deciphering neurologic function is a daunting task, requiring understanding the neuronal
networks and emergent properties that arise from the interactions among single neurons …