One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Bacterial keratitis is a common corneal infection that is treated with topical antimicrobials. By
the time of presentation there may already be severe visual loss from corneal ulceration and …

For the treatment and prevention of ocular diseases, most patients are treated with
conventional drug delivery formulations such as eye drops or ointments. However, eye …

Penetration of antibiotics into and through the cornea is a major limiting factor in the
treatment of ocular infections. Several strategies are in vogue to overcome this limitation …

The aim of this work was to evaluate the effectiveness of neat chitosan (CS) and its
derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AAMPS) and [2 …

Corneal and conjunctival infections are common ocular diseases, sometimes, causing
severe and refractory drug-resistant bacteria infections. Fungal keratitis is a leading cause …

The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at
effective concentrations over desired periods of time has been an active topic of research …

The efficacy of conventional ocular formulations is limited by poor corneal retention and
permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS) …

Contact lens‐associated microbial keratitis poses a diagnostic dilemma for optometrists on
two fronts. The distinction between sterile inflammation and microbial infection is often …