BACKGROUND: The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in
the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A …

Human clear cell renal cell carcinoma (CCC) remains resistant to treatments despite the
progress in targeted therapies. Several signaling pathways acting during renal development …

Gap junctions are plasma membrane channels comprising connexin proteins that mediate
intercellular permeability and communication. The presence, composition, and function of …

Aim: Biological and epidemiologic data suggest that 1 alpha, 25 dihydroxyvitamin D3 (1, 25
(OH) 2D3) levels may influence development of renal cell carcinoma. The vitamin D receptor …

Results In recent years, vitamin D has received vast attention due to suggestions that it may
have a crucial role in the prevention and therapy of various cancers. Many epidemiologic …

Obesity has been linked to the incidence and mortality of several malignancies, including
prostate and renal cancer. Increased body mass appears to have a more consistent …

In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity
through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily …

Background There is increasing evidence that vitamin D metabolites influence
carcinogenesis. Besides its role in mineral homoeostasis, calcitriol, the active metabolite of …

Within the past three to four decades a revolution has occurred in our understanding of
vitamin D and its effects. Sundry laboratory and epidemiologic studies have revealed that …

Background Although the kidney is a primary organ for vitamin D metabolism, the
association between vitamin D and renal cell cancer (RCC) remains unclear. Methods We …