Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …

Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness,
is critical to patients' outcomes. However, many orally administered therapeutic drugs are …

Background During the elderly, hippocampal neurogenesis and synaptogenesis reduce and
dark neurons (DNs) increase, leading to cognitive impairment. It is believed that natural …

Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by the
appearance of painful inflamed nodules, abscesses, and pus-draining sinus tracts in the …

Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory
disease characterized by painful skin lesions that occur in the axillary, inguinal, gluteal and …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Despite significant
advances in medical treatment, chemotherapy as monotherapy can lead to substantial side …

Objective: Grape hybrids are characterized by different chemical compositions; often with
high hybrids are characterized by different chemical compositions, often with a high phenolic …

Imatinib is an oral molecular targeted therapy that acts as a tyrosine kinase inhibitor.
Silkworms present a promising experimental model for elucidating the pharmacokinetic and …

Abstract Background and Objective Imatinib is primarily transported into the liver by organic
cation transporter 1 (OCT1), organic anion transporting polypeptide 1B3 (OATP1B3), and …

Bioactive compounds of plant origin are used all over the world because of their positive
impact on human and animal health and because of their beneficial, specific properties. The …