Peptide-based anticancer vaccination aims at stimulating an immune response against one
or multiple tumor-associated antigens (TAAs) following immunization with purified …

CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs
that were originally discovered in bacterial DNA, are demonstrated not only as potent …

Primary tumors may create the premetastatic niche in secondary organs for subsequent
metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles …

Simple Summary Cancer is one of the main causes of death worldwide and early detection
is crucial for effective treatment. Scientists have therefore focused on the identification of …

Purpose: OX40 agonist–based combinations are emerging as a novel avenue to improve
the effectiveness of cancer immunotherapy. To better guide its clinical development, we …

When compartmentally mislocalized within cells, nucleic acids can be exceptionally
immunostimulatory and can even trigger the immune-mediated elimination of cancer …

Nucleic acids (DNA and RNA) have been recognized as promising building blocks to
fabricate a variety of well-defined two-and three-dimensional architectures through the …

Cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODNs), which exist in vertebrate,
bacterial, and viral genomes, are regarded as strong immune adjuvants. To date, the …

The development of cancer occurs when immunosuppression inhibits the naturally occurring
process through which the immune system recognizes and eliminates cancer cells (ie the …

Auto-antibodies are classically associated with autoimmune diseases, where they are an
integral part of diagnostic panels. However, recent evidence is accumulating on the …