Lung deposition and systemic bioavailability of dose delivered to smoker compared with non‐smoker COPD subjects

BME Mohamed, R Salah Eldin… - … Journal of Clinical …, 2021 - Wiley Online Library
Introduction Inhaled drugs are the most commonly used class of medications for COPD
subjects. No studies have been performed to assess the influence of smoking on lung …

FBXO44-MEDIATED DEGRADATION OF RGS2

HJ McNabb - 2023 - hammer.purdue.edu
G Protein Coupled Receptor (GPCR) signaling plays a key role in intercellular
communication and regulates many physiological processes relevant to disease …

[PDF][PDF] A Review on Novel Approaches to the Treatment of Asthma

UF Shaikh, K Borderwala, V Chauhan, R Dedania… - 2023 - journals.bmusurat.ac.in
Asthma is among the most prevalent disorders of the respiratory system, affecting more than
300 million people worldwide. It is a heterogeneous and intricate inflammatory disease of …

Purinergic signalling in testicular peritubular cells

A Missel - 2022 - edoc.ub.uni-muenchen.de
Extracellular ATP and its metabolites, as part of the purinergic signalling system, act via
membrane receptors and fulfil important roles in the body. However, in the testis this …

[引用][C] Synthesis of G Protein-Biased Ligands for Serotonin 5-HT1A and β-Adrenergic Receptors

TG Albert - 2022 - Dissertation, Erlangen, Friedrich …

Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma

H Cui, R Duan, H Niu, T Yu, K Huang, C Chen… - BMC Pulmonary …, 2022 - Springer
Background Bronchial asthma is a heterogeneous disease with distinct disease phenotypes
and underlying pathophysiological mechanisms. Long non-coding RNAs (lncRNAs) are …

[PDF][PDF] mPGES-inhibitor in HumanLung Fibroblasts Pharmaceutical evaluation for design of novel therapies in asthma disease

B Militeano - 2022 - diva-portal.org
Background: Asthma is a respiratory chronic disease characterized by repeated outbreaks of
shortness of breath, chest tightness, wheezing and coughing attacks. The hallmark features …

[图书][B] Molecular mapping of the protein kinase A pathway: mutations, models, and mechanisms

DJ Ramms - 2021 - search.proquest.com
As a central regulatory hub, protein kinase A (PKA) coordinates numerous biological
processes, including discrete effects on metabolic enzymes all the way to global effects on …

Interleukin-33 in patients with bronchial asthma and its relation to disease severity

AN Ahmed, NM Ayoub, R Sabry… - The Scientific Journal of …, 2021 - journals.lww.com
Background Bronchial asthma (BA) is a chronic inflammatory disorder of the airways,
characterized by bronchial hyperresponsiveness and variable airflow obstruction. Interleukin …

Molecular simulations of G protein-coupled receptors: A journey into structure-based ligand design and receptor function

P Matricon - 2021 - diva-portal.org
Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand
design and receptor function diva-portal.org Digitala Vetenskapliga Arkivet Simple search …