Structure-based virtual screening for ligands of G protein–coupled receptors: what can molecular docking do for you?
F Ballante, AJ Kooistra, S Kampen, C de Graaf… - Pharmacological …, 2021 - ASPET
G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins in
the human genome and are important therapeutic targets. During the last decade, the …
the human genome and are important therapeutic targets. During the last decade, the …
Airway smooth muscle pathophysiology in asthma
B Camoretti-Mercado, RF Lockey - Journal of Allergy and Clinical …, 2021 - Elsevier
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …
constitutes an important target for treatment. These cells control muscle tone and thus …
Gαs–Protein kinase a (PKA) pathway signalopathies: the emerging genetic landscape and therapeutic potential of human diseases driven by aberrant Gαs-PKA …
Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …
GPCR mediated control of calcium dynamics: A systems perspective
G-protein coupled receptor (GPCR) mediated calcium (Ca 2+)-signaling transduction
remains crucial in designing drugs for various complex diseases including …
remains crucial in designing drugs for various complex diseases including …
The biology of prostaglandins and their role as a target for allergic airway disease therapy
K Lee, SH Lee, TH Kim - International journal of molecular sciences, 2020 - mdpi.com
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid
via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and …
via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and …
Pharmacology of adenosine receptors: Recent advancements
F Vincenzi, S Pasquini, C Contri, M Cappello, M Nigro… - Biomolecules, 2023 - mdpi.com
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …
Targeting GPCR signaling for idiopathic pulmonary fibrosis therapies
AJ Haak, MT Ducharme, AMD Espinosa… - Trends in …, 2020 - cell.com
A variety of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis
of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By …
of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By …
[HTML][HTML] A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention
Lungs are important respiratory organs primarily involved in gas exchange. Lungs interact
directly with the environment and their primary function is affected by several inflammatory …
directly with the environment and their primary function is affected by several inflammatory …
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
J Perez-Garcia, M Pino-Yanes, EG Plender… - Clinical …, 2023 - Springer
Background Albuterol is the first-line asthma medication used in diverse populations.
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and …
[PDF][PDF] S-nitrosylation is required for β2AR desensitization and experimental asthma
FV Fonseca, TM Raffay, K Xiao, PJ McLaughlin, Z Qian… - Molecular cell, 2022 - cell.com
The β 2-adrenergic receptor (β 2 AR), a prototypic G-protein-coupled receptor (GPCR), is a
powerful driver of bronchorelaxation, but the effectiveness of β-agonist drugs in asthma is …
powerful driver of bronchorelaxation, but the effectiveness of β-agonist drugs in asthma is …