Atherosclerosis is a chronic inflammatory disease and the pathological basis of many fatal
cardiovascular diseases. Macrophages, the main inflammatory cells in atherosclerotic …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

While mouse remains the most popular model, the conservation of parental-to-embryonic
epigenetic transition across mammals is poorly defined. Through analysis of oocytes and …

Abstract Background Circular RNAs (circRNAs) represent a novel class of non‐coding RNAs
formed by a covalently closed loop and play crucial roles in many biological processes …

Abstract N 6-methyladenosine (m 6 A) is one of the most widespread and highly conserved
chemical modifications in cellular RNAs of eukaryotic genomes. Owing to the development …

Natural and artificial directional selections have resulted in significantly genetic and
phenotypic differences across breeds in domestic animals. However, the molecular …

DNA methylation (5mC) and mRNA N 6-methyladenosine (m 6 A) play an essential role in
gene transcriptional regulation. DNA methylation has been well established to be involved …

Circular RNAs (circRNAs) represent a class of covalently closed single-stranded RNA
molecules that are emerging as essential regulators of various biological processes. The …

Cell identity is determined by the chromatin structure and profiles of gene expression, which
are dependent on chromatin accessibility and DNA methylation of the regions critical for …

Skeletal myogenesis is a highly ordered process finely regulated by various factors. Long
non-coding RNAs play an important regulatory role in myogenesis via multiple mechanisms …