Natural product-driven dual COX-LOX inhibitors: Overview of recent studies on the development of novel anti-inflammatory agents

N Mukhopadhyay, A Shukla, PN Makhal, VR Kaki - Heliyon, 2023 - cell.com
Inflammation is a complicated physiological process that results in a variety of disorders.
Several inflammatory mediators are produced during this process, which is responsible for …

Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

OM Alshehri, A Zeb, SM Mukarram Shah… - Frontiers in …, 2024 - frontiersin.org
The strong ethnopharmacological utilization of Isodon rugosus Wall. Ex. Benth is evident in
the treatment of several types of pain and inflammation, including toothache, earache …

Phytochemistry, anti-diabetic and antioxidant potentials of Allium consanguineum Kunth

MH Mahnashi, YS Alqahtani, AO Alqarni… - … medicine and therapies, 2022 - Springer
Aim The study was planned to investigate the phytochemicals, antidiabetic and antioxidant
studies of A. consanguineum. Methods The preliminary studies were performed on crude …

[Retracted] Phytochemical Analysis, Total Phenolic, Flavonoid Contents, and Anticancer Evaluations of Solvent Extracts and Saponins of H. digitata

OM Alshehri, S Alshamrani… - BioMed Research …, 2022 - Wiley Online Library
Cancer is one of the most challenging diseases in the modern era for the researchers and
investigators. Extensive research worldwide is underway to find novel therapeutics for …

Anti‐Inflammatory Potentials of β‐Ketoester Derivatives of N‐Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies

YS Alqahtani, MS Jan, MH Mahnashi… - Journal of …, 2022 - Wiley Online Library
Inflammation, being a well‐known and complex pathological condition, is always a
challenge to the human health. This research work was designed for a rationale‐based anti …

Exploration of succinimide derivative as a multi-target, anti-diabetic agent: in vitro and in vivo approaches

MH Mahnashi, W Alam, MA Huneif, A Abdulwahab… - Molecules, 2023 - mdpi.com
Diabetes mellitus (DM) is counted among one of the leading challenges in the recent era,
and it is a life-threatening disorder. Compound 4-hydroxy 3-methoxy phenylacetone …

[PDF][PDF] Research article phytochemical analysis, total phenolic, flavonoid contents, and anticancer evaluations of solvent extracts and saponins of H. Digitata

OM Alshehri, S Alshamrani, MH Mahnashi… - Angiogenesis, 2022 - academia.edu
Cancer is a challenging disease worldwide because it is a major cause of mortality and
morbidity [1]. Due to cancer, death ratio is almost high when compared to other diseases like …

Identification and Absorption–Distribution–Metabolism–Excretion–Toxicity Prediction of Potential MTHFD2 Enzyme Inhibitors from Urtica dioica Ethanolic Leaf Extract

SO Alshammari - Processes, 2024 - mdpi.com
This study aimed to explore the potential of Urtica dioica (U. dioica) ethanolic leaf extract for
cancer treatment by identifying its components, evaluating its effects on cancer cell lines …

Investigating the Bioactive Potential of Persicaria hydropiper: GC-MS profiling and In vivo Exploration of Antinociceptive and Antidiarrheal Effects

M Chowdhury, TJ Ritu, N Nahar - Journal of Applied Life …, 2024 - archive.article4submit.com
Aims: This study aimed to investigate the impact of methanol-derived leaf extracts from the
Persicaria hydropiper plant on the GCMS analysis and in-vivo antinociceptive and …

Design, Synthesis, Molecular Docking, and Anti‐Inflammatory Potential of Amide Coupling Carboxylate Derivatives

HS Akbar, N Muhammad, MS Jan, R Zafar… - …, 2024 - Wiley Online Library
Eight new amide‐based carboxylate derivatives were synthesized and evaluated for anti‐
inflammatory potentials using in‐vitro, in‐vivo and in silico studies. In cyclooxygenase‐2 …