Cocaine use disorder (CUD) is a significant public health issue that generates substantial
personal, familial, and economic burdens. Still, there are no FDA-approved …

Cocaine use disorder and post-traumatic stress disorder (PTSD) commonly co-occur. This
could be due to vulnerability to post-traumatic symptoms conferred by previous exposure to …

Cocaine addiction is a behavioral disorder defined by behavioral symptoms that set it apart
from nondisordered forms of drug use. Here we review evidence in rats (the most frequently …

Substance use disorder (SUD) is a heterogeneous disorder, where severity, symptoms, and
patterns of substance use vary across individuals. Yet, when rats are allowed to self …

Novelty seeking is a personality trait associated with an increased vulnerability for
substance abuse. In rodents, elevated novelty seeking has been shown to be a predictor for …

Drug addiction is a chronic relapsing multifactorial disorder arising as a result of the
interaction between biological and environmental factors and characterized by a loss of …

Repeated cocaine administration induces many long-term structural and molecular changes
in the dorsal medial prefrontal cortex (dmPFC) and are known to underlie aspects of cocaine …

Background: Orexin-A (OrxA) administration in the posterior paraventricular nucleus of the
thalamus (pPVT) reinstates extinguished cocaine-seeking behaviour following extended …

The capacity to motivate behavioral action in the face of anticipated environmental
challenge is a critical adaptive process. Acute stressors can invigorate actions to avoid …

Drug users instrumentalize the drug dosing-timing relationship (ie preferred drug dose in the
preferred time) to produce their desired effects (ie euphoria, withdrawal avoidance, etc.) …