Heightened anxiety and sensitivity to stress following chronic cocaine use are likely to
increase an individual's susceptibility for relapse to drug-seeking behavior. Thus, it is …

Clinicians and researchers alike have long believed that stressors play a pivotal etiologic
role in risk, maintenance, and/or relapse of alcohol and other substance use disorders …

The stress response is a co-ordinated reaction to real or perceived threats. One arm of the
response is the hypothalamic-pituitary-adrenal axis, initiated by corticotropin-releasing factor …

Rationale. 3, 4-methylenedioxymethamphetamine (MDMA) and methamphetamine are two
amphetamine derivatives with contrasting pharmacological profiles. Therefore, self …

Recent studies suggest that the temporal pattern of drug use (pharmacokinetics) has a
profound effect on the ability of self-administered cocaine to produce addiction-like behavior …

Stressors clearly contribute to addiction etiology and relapse in humans, but our
understanding of specific mechanisms remains limited. Rodent models of addiction offer the …

Drug addiction affects tens of millions of people worldwide and yet there is no biological
marker for diagnosis and available treatment options remain largely ineffective. Interestingly …

L'addiction à la cocaïne est un trouble comportemental qui touche plusieurs millions de
personnes en Europe. L'étude des mécanismes neurobiologiques de ce trouble repose …

Stress contributes to numerous psychiatric disorders. CRF signaling in the bed nucleus of
the stria terminalis (BNST) drives negative affective behaviors, thus agents that decrease …

Botulinum neurotoxins (BoNTs) are the most lethal natural toxins produced by C. botulinum.
Among the seven serotypes (AG) discovered, the most potent serotype A has a lethal dose …