Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …

Rapid bench-to-bedside translation of basic immunology to cancer immunotherapy has
revolutionised the clinical practice of oncology over the last decade. Immune checkpoint …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis because of its high
propensity to metastasize and its immunosuppressive microenvironment. Using a panel of …

Queuosine is one of the most complex hypermodified RNA nucleosides found in the Wobble
position of tRNAs. In addition to Queuosine itself, several further modified derivatives are …

Selective autophagy is a defense mechanism by which foreign pathogens and abnormal
substances are processed to maintain cellular homeostasis. Sequestosome 1 …

Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell
carcinoma (RCC). Most of the therapeutic agents mediate cancer cell death through …

Background The diverse and complex attributes of cancer have made it a daunting
challenge to overcome globally and remains to endanger human life. Detection of critical …

Single-cell RNA sequencing can reveal valuable insights into cellular heterogeneity within
tumour microenvironments (TMEs), paving the way for a deep understanding of cellular …

Overcoming replicative senescence is an essential step during oncogenesis, and the
reactivation of TERT through promoter mutations is a common mechanism. TERT promoter …