Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …

Mutations, the irreversible changes in an organism's DNA sequence, are present in tissues
at a variant allele frequency (VAF) ranging from~ 10-8 per bp for a founder mutation to~ 10-3 …

Alterations of the tumor suppressor TP53, one of the most common events in cancer, alone
are insufficient for tumor development but serve as drivers of transformation. We sought to …

Simple Summary Drug tolerant persister (DTP) cells are a unique, small sub-population of
cancer cells that maintain viability under anti-cancer cytotoxic treatments. These cells enter …

Accurate detection of somatic structural variation (SV) in cancer genomes remains a
challenging problem. This is in part due to the lack of high-quality, gold-standard datasets …

Introduction Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized
as a distinct subset of lung cancer, with unique biology, disease course, and treatment …

Large sets of whole cancer genomes make it possible to study mutation hotspots genome-
wide. Here we detect, categorize, and characterize site-specific hotspots using 2279 whole …

The sparsity of mutations observed across tumours hinders our ability to study mutation rate
variability at nucleotide resolution. To circumvent this, here we investigated the propensity of …

Motivation The accumulation of somatic mutations plays critical roles in cancer development
and progression. However, the global patterns of somatic mutations, especially non-coding …

Cancer genomics tailors diagnosis and treatment based on an individual's genetic
information and is the crux of precision medicine. However, analysis and maintenance of …