Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

F Pellati, V Borgonetti, V Brighenti… - BioMed research …, 2018 - Wiley Online Library
In the last decades, a lot of attention has been paid to the compounds present in medicinal
Cannabis sativa L., such as Δ9‐tetrahydrocannabinol (Δ9‐THC) and cannabidiol (CBD) …

[HTML][HTML] The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Cannabinoid hyperemesis syndrome: diagnosis, pathophysiology, and treatment—a systematic review

CJ Sorensen, K DeSanto, L Borgelt, KT Phillips… - Journal of Medical …, 2017 - Springer
Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with
cannabis use. Our objective is to summarize the available evidence on CHS diagnosis …

[HTML][HTML] Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder

MN Hill, P Campolongo, R Yehuda… - …, 2018 - nature.com
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

SB Raut, PA Marathe, L van Eijk, R Eri… - Pharmacology & …, 2022 - Elsevier
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

M Kohno, J Link, LE Dennis, H McCready… - Pharmacology …, 2019 - Elsevier
Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …

[HTML][HTML] Targeting cannabinoid signaling in the immune system:“High”-ly exciting questions, possibilities, and challenges

A Oláh, Z Szekanecz, T Bíró - Frontiers in Immunology, 2017 - frontiersin.org
It is well known that certain active ingredients of the plants of Cannabis genus, ie, the
“phytocannabinoids”[pCBs; eg,(−)-trans-Δ9-tetrahydrocannabinol (THC),(−)-cannabidiol …

[HTML][HTML] Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming

A Angelina, M Pérez-Diego, J López-Abente… - Mucosal …, 2022 - nature.com
The generation of functional regulatory T cells (Tregs) is essential to keep tissue
homeostasis and restore healthy immune responses in many biological and inflammatory …

[HTML][HTML] Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono …

C Depommier, RM Vitale, FA Iannotti, C Silvestri… - Cells, 2021 - mdpi.com
Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in
the context of obesity and associated metabolic disorders. Although a first proof-of-concept …

Efficacy of cannabinoids in a pre-clinical drug-screening platform for Alzheimer's disease

D Schubert, D Kepchia, Z Liang, R Dargusch… - Molecular …, 2019 - Springer
Finding a therapy for Alzheimer's disease (AD) is perhaps the greatest challenge for modern
medicine. The chemical scaffolds of many drugs in the clinic today are based upon natural …