▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

The endosomal pathway of antigen presentation leads to the display of peptides on major
histocompatibility complex (MHC) class II molecules at the cell surface of antigen‐presenting …

Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II–
restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in …

Human leukocyte antigen DM (HLA-DM) molecules are structurally related to classical MHC
class II molecules and reside in the lysosomallke compartment where class II-restricted …

Destruction of Ii by proteolysis is required for MHC class II molecules to bind antigenic
peptides, and for transport of the resulting complexes to the cell surface. The cysteine …

Abstract A complex between HLA-DR3 and a fragment of invariant chain called CLIP was
isolated from a human cell line defective in antigen presentation and its X-ray crystal …

Cathepsins have been implicated in the degradation of proteins destined for the MHC class
II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator …

). First, in the endoplasmic reticulum (ER), newly synthesized class II α and β chains
associate with the invariant (Ii) chain to form a complex that itself is incapable of binding …

Containment of hepatitis C virus (HCV) and other chronic human viral infections is
associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of …

HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …