Some of the most pressing challenges associated with interstitial lung disease (ILD) are how
best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD) …

Pulmonary fibrosis is the end stage of many diffuse parenchymal lung diseases. It is
characterised by excessive matrix formation leading to destruction of the normal lung …

Unbiased genetic studies have uncovered surprising molecular mechanisms in human
cellular immunity and autoimmunity. We performed whole-exome sequencing and targeted …

Pulmonary complications are an important extra-articular feature of autoimmune rheumatic
diseases and a major cause of mortality. The underlying pathogenesis probably involves …

Background Patients with interstitial lung disease (ILD) may have features of an autoimmune
disorder that do not meet the diagnostic criteria for connective tissue diseases. We …

This commentary highlights the present dilemmas surrounding the classification of a patient
with interstitial pneumonia who has clinical features suggesting an associated connective …

Background Interstitial lung disease (ILD) frequently complicates connective tissue diseases
(CTDs). Glucocorticoids and immunomodulatory agents are regarded as mainstays of …

In recent years, personalized or precision medicine has made effective inroads into the
management of diseases, including respiratory diseases. The route to implementing this …

Systemic lupus erythematosus (SLE) is a potentially severe, frequently disabling
autoimmune disease with multiorgan involvement and a typically waxing and waning …

The widespread use of high-resolution computed tomography in clinical and research
settings has increased the detection of interstitial lung abnormalities (ILA) in asymptomatic …